Large-scale genome remodelling by the developmentally programmed elimination of germ line sequences in the ciliate Paramecium.
نویسنده
چکیده
In Paramecium, during the development of the somatic macronucleus, precise excision of thousands of single-copy non-coding sequences is initiated by specific DNA double-strand breaks, while imprecise elimination of germ-line-limited repeated sequences leads to internal deletions or chromosome fragmentation. Recent data point to a role of non-coding RNAs in the epigenetic programming of these rearrangements.
منابع مشابه
Transposon Invasion of the Paramecium Germline Genome Countered by a Domesticated PiggyBac Transposase and the NHEJ Pathway
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ورودعنوان ژورنال:
- Research in microbiology
دوره 155 5 شماره
صفحات -
تاریخ انتشار 2004